Heparan Sulfate Proteoglycan (Large) / Perlecan MBS438798 from MyBioSource.com

Product Specs
ItemHeparan Sulfate Proteoglycan (Large) / Perlecan
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS438798
Quantity0.1 mg
ApplicationsFlow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
ConcentrationPurified Ab with BSA and Azide at 200ug/ml
Conjugate/TagUnconjugated
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml
ReactivityHuman, Monkey, Cow, Pig, Mouse, Fish
TargetHeparan Sulfate Proteoglycan / Perlecan
IsotypeIgG2a kappa
Molecular WeightAntigen: >400kDa
CloneA7L6
HostRat
ImmunogenThis MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment
NCBI Full Gene Nameheparan sulfate proteoglycan 2
NCBI Gene AliasesPRCAN, SJS, SJS1, HSPG, PLC, SJA
ClonalityMonoclonal